Spice drug / K2 Spice / Synthetic Cannabinoids

Synthetic cannabinoids/spice drug / k2 spice / k2 drug are a type of designer medication that binds to the same receptors that cannabinoids (THC, CBD, and others) in cannabis plants do. These unique psychoactive compounds should not be confused with synthetic phytocannabinoids (chemically synthesized THC or CBD) or synthetic endocannabinoids, from which they differ in numerous ways.

Synthetic cannabinoids are often sprayed onto plant matter and smoked, though they have also been eaten in a concentrated liquid form in the United States (US) and the United Kingdom (UK) since 2016. They have been advertised as herbal incense or “herbal smoking blends”[6] and sold under brand names such as K2, spice, and synthetic marijuana. They are frequently labeled “not for human consumption” to avoid liability. To evade legal limits on cannabis, a huge and complicated range of synthetic cannabinoids are produced, creating synthetic cannabinoids designer pharmaceuticals.

The majority of synthetic cannabinoids are cannabinoid receptor agonists. They were created to be similar to THC, the natural cannabinoid having the highest binding affinity to the CB1 receptor, which is connected to the psychoactive effects or “high” of marijuana. These synthetic analogs frequently have higher binding affinity and efficacy to CB1 receptors. There are several synthetic cannabinoid families (e.g., AM-xxx, CP-xx,xxx, HU-xx, JWH-xxx) that are classified by the substance’s creator (e.g., JWH stands for John W. Huffman) and can include several substances with different base structures, such as classical cannabinoids and unrelated naphthoylindoles.

Street Names

What does spice drug it looks like?

These chemical compounds are typically encountered in bulk powder form before being dissolved in solvents such as water.

before being added to dry plant material to create “herbal incense” goods. Local distributors package the dry plant material for retail distribution after applying the medication to it. Because these goods have no recognized medical application, this process is carried out without regard for pharmaceutical-grade chemical purity standards or the user’s safety. It disregards any control systems that would ensure a consistent concentration of the potent and hazardous medications contained in each package.

The disregard for public safety, as well as frequently found “hot spots” in drug packaging, can result in a user eating a highly concentrated percentage of the drugs without their knowledge, often leading to major adverse health effects. The bulk powder can also be dissolved in a solution for e-cigarettes or other vaping devices.

What is the effect of spice drug on the body?

In reaction to the negative health effects connected with the usage of herbal incense items containing these synthetic cannabinoids, state public health and poison control centers have issued warnings. Tachycardia (rapid heart rate), high blood pressure, unconsciousness, tremors, seizures, vomiting, hallucinations, agitation, anxiety, pallor, numbness, and tingling were among the side effects. This is in addition to the several public health and poison control centers that have issued similar warnings about the usage of these synthetic cannabinoids.
In rare cases, the negative health effects can remain even after the consumer stops using the substances.

What are its overdose effects?

The usage of synthetic cannabinoids has been linked to severe side effects such as nausea, vomiting, agitation, anxiety, seizures, stroke, coma, and death by heart attack or organ failure. The Centers for Disease Control and Prevention has also reported acute renal impairment necessitating hospitalization and dialysis in numerous people who allegedly smoked synthetic cannabis.

Which drugs cause similar effects?

Synthetic cannabinoids are touted as an alternative to THC, marijuana’s major psychoactive element; nevertheless, they are significantly more potent and have been demonstrated to induce more severe negative effects than THC.

What is the effect Spice Drug on the mind?

The usage of these synthetic cannabinoids has been linked to acute psychotic episodes, dependency, and withdrawal. Some people have experienced vivid hallucinations. Other side effects include acute agitation, disordered thoughts, paranoid delusions, and violence after consuming these substances.

What is the legal status of Spice Drug in the United States?

These chemicals have no acknowledged medical use in the United States and have been linked to negative health outcomes. Currently, 43 drugs have been designated as Schedule I substances under the Controlled drugs Act, either through law or through regulatory action. Furthermore, several other synthetic cannabinoids fulfill the criteria of “cannabimimetic agent” under the Controlled Substances Act and are thus Schedule I substances.

Many synthetic cannabis drugs are being offered as “incense,” “potpourri,” and other non-controlled substance goods. Synthetic cannabinoids, on the other hand, may be prosecuted under the Controlled Substance Analogue Enforcement Act, which allows non-controlled medications to be classified as Schedule I controlled substances if specific requirements are met. Using the Controlled Substance Analogue Enforcement Act, the DEA has effectively investigated and convicted those trafficking and selling these dangerous narcotics.

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