Synthetic cannabinoids are known by a variety of names, including K2. It is created by spraying man-made chemicals onto shredded, dried plant material. It is classified as a designer drug because its composition is similar to but not identical to that of cannabis (or marijuana). Because its molecular structure differs from illicit drugs, it is legal in states where cannabis is not. This also means that it has a similar but far more potent effect on the brain than cannabis.
Synthetic cannabinoids act on the same brain receptors (cannabinoid receptors) as tetrahydrocannabinol (or THC, the active ingredient in marijuana), albeit more intensely.
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THC is a partial agonist for cannabinoid receptors, which means it binds to them but only elicits a partial response. Synthetic cannabinoids are full agonists, which means they elicit the strongest response possible and have been shown to be up to 660 times more potent than cannabis in some studies. In addition, they bind to cannabinoid receptors more readily than THC. Their affinity for cannabinoid receptors is thought to be 4-5 times that of THC.
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